Selected Publications
Molecular Neuro-Oncology Laboratory
E. Antonio Chiocca, M.D. Ph.D.

Dr Chiocca | Chiocca Laboratory Molecular Neuro-Oncology Laboratory | Links

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Chiocca Publications Chiocca Pubs 2003 Chiocca Pubs 2002 Chiocca Pubs 2001 Chiocca Pubs 2000 Chiocca Pubs 1999

2. Davies P.J.A., Chiocca E.A., Stein J.P.: Retinoid?regulated expression of tissue transglutaminase in normal and leukemic myeloid cells. Adv. Exp. Med. Biol. 231: 63-71, 1988.

3. Chiocca E.A., Davies P.J.A., Stein J.P.: The molecular basis of retinoic acid action: transcriptional regulation of tissue transglutaminase gene expression in macrophages J. Biol. Chem. 263: 11584?11589, 1988.

4. Davies P.J.A., Basilion J.P., Chiocca E.A., Johnson J., Poddar S., Stein J.P.: Retinoids as generalized regulators of cellular growth and differentiation Am. J. Med. Sci. 296: 164-170, 1988.

5. Davies P.J.A., Chiocca E.A., Basilion J.P., Poddar S., Stein J.P.: Transglutaminases and their regulation: implications for polyamine metabolism. Adv. Exp. Med. Biol. 250: 391-401, 1988.

6. Chiocca E.A., Davies P.J.A., Stein J.P.: Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation J. Cell. Biochem. 39: 293?304, 1989.

7. Lee J.K., Kim T.S., Chiocca E.A., Medhkour A., Martuza R.L.: Growth of human schwannomas in the subrenal capsule of the nude mouse. Neurosurgery 26: 598?605, 1990.

8. Lee J.K., Choi B., Sobel R.A., Chiocca E.A., Martuza R.L.: Inhibition of growth and angiogenesis of a human neurofibrosarcoma by heparin and hydrocortisone J. Neurosurg. 73: 429?435, 1990.

9. Citterio F., Chiocca E.A., Kahan B.D.: Nuclear effects of cyclosporin. Transplantation Proceedings 22: 1742?1743, 1990.

10. Chiocca E.A., Choi B.B., Cai W., DeLuca N.A., Schaffer P.A., DiFiglia M., Breakefield X.O., Martuza R.L.: Transfer and expression of the lac Z gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol. 2: 739?746, 1990.

11. Martuza R.L., Chiocca E.A., Jenike M. L., Ballantine H.T.: Stereotactic radiofrequency thermal cingulotomy for obsessive?compulsive disorders. J. Neuropsych. and Clin. Neurosci. 2: 331?336, 1990.

12. Gentile V., Saydak M.M., Chiocca E.A., Akande N., Birkbichler P.J., Lee K.N., Stein J.P., Davies P.J.A.: Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J. Biol. Chem. 262: 478?483, 1991.

13. Lee J.K., Sobel R.A., Chiocca E.A., Kim T.S., Martuza R.L. Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. J. Neuro-oncol. 14, 101-12, 1992.

14. Yu J., Wei M.X., Chiocca E.A., Martuza R.L., Tepper R.L.: Treatment of human glioma by engineered interleukin-4 secreting cells. Cancer Res 53, 3125-3128, 1993.

15. Chiocca E.A., Tamiya T., Boviatsis, E.J., Filipek, P.A., Breakefield X.O., Kennedy D.N.: Gene therapy for gliomas using virus vectors. Neuroimmunol. Res. 6 (Japan), 23-32, 1993.

16. Boviatsis E.J., Chase M., Wei M.X., Tamiya T., Hurford R.K. Jr., Kowall N.W., Tepper R.I., Breakefield X.O., Chiocca E.A.: Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus (HSV), and retrovirus vectors. Human Gene Therapy 5, 183-191, 1994.

17. Pakzaban P. and Chiocca E.A : Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum. NeuroReport 5, 993-996, 1994.

18. Scharf J.M., Boviatsis E.J., Fleet C., Breakefield X.O., and Chiocca E.A.: Genetically modified rat 9L gliosarcoma cells facilitate detection of infiltrating tumor cells in a rat model of brain neoplasms. Transgenics 1, 219-224, 1994.

19. Wei, M.X., Tamiya, T., Chase, M., Boviatsis, E.J., Chang, T.K.H., Hochberg, F.H., Kowall, N.W., Waxman, D.J., Breakefield, X.O., Chiocca, E.A. Experimental tumor therapy in mice with the cyclophosphamide-activating cytochrome P450 2B1 gene. Human Gene Therapy 5, 969-978, 1994.

20. Boviatsis E.J., Scharf J.M., Chase M., Harrington K., Breakefield X.O., Chiocca E.A.: Antitumor activity and reporter gene transfer into rat brain neoplasms inculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene Therapy 1, 323-331, 1994.

Chiocca, E.A. and Breakefield, X.O. (Editors): Gene therapy for neurological disorders and brain tumors. Humana Press, Totowa, NJ, 1997.

REVIEWS

1. Kramm, C.M., Sena-Esteves, M., Barnett, F.H., Rainov, N.G., Schuback, D.E., Yu, J.S., Pechan, P.A., Paulus, W., Chiocca, E.A., Breakefield, X.O.: Gene Therapy for Brain Tumors (Review). Brain Pathology 5: 345-381, 1995

2. Qureshi, N.H., Chiocca, E.A.: A review of gene therapy for the treatment of central nervous system tumors. Crit Rev Oncog 10: 261-74, 1999.

3. Smith, E.R. and Chiocca, E.A.: Oncolytic viruses and tumors: turning one scourge against another. Expert Opin Investig Drugs. 9: 311-27, 2000.

4.Lim DJ, Rubenstein AE, Evans DG, Jacks T, Seizinger BG, Baser ME, Beebe D, Brackmann DE, Chiocca EA, Fehon RG, Giovannini M, Glazer R, Gusella JF, Gutmann DH, Korf B, Lieberman F, Martuza R, McClatchey AI, Parry DM, Pulst SM, Ramesh V, Ramsey WJ, Ratner N, Rutkowski JL, Ruttledge M, Weinstein DE: Advances in Neurofibromatosis 2 (NF2): A Workshop Report. J Neurogenet. 14: 63-106, 2000.

BOOK CHAPTERS

1. Davies P.J.A., Basilion J.P., Chiocca E.A., Fung W.W., Duvic M., Stein J.P.: Retinoid?regulated gene expression in normal and transformed cells: transcriptional activation of tissue transglutaminase gene expression. In: Pharmacology of Retinoids in the Skin (U. Reichert and B. Schrote, eds.) Kargel Publishers Basel, vol.3 pp. 20-28, 1989.

2. Chiocca E.A. and Martuza R.L.: Neurosurgical therapy of the obsessive?compulsive disorder. In: Obsessive-Compulsive Disorder. Diagnosis and Treatment. (Jenike M.L., Baer L., Minichiello L., eds.), pp. 283-294, 1990.

3. Davies P.J.A., Stein J.P., Chiocca E.A., Basilion J.P., Gentile V., Thomazy V., Fesus L.: Retinoid-regulated expression of transglutaminases: links to the biochemistry of programmed cell death. In: Retinoids and Development (Morris?Kay G., ed.), Oxford University Press, pp. 249-263, 1991.

4. Chiocca E.A., Andersen J.K., Takamiya Y., Martuza R.L., Breakefield X.O. Virus-mediated Genetic Treatment of Rodent Gliomas. In: Gene Therapeutics. J.A. Wolff ed. (Birkhauser Press Publishing Co., Boston), 1994, pp. 245-262.

5. Chiocca, E.A.: Genetic treatment of brain tumors with the cyclophosphamide-activating CYP2B1 gene. Clinical Neurosurgery vol.42, 1995, pp. 370-382.

6. Wei, M.X., Tamiya, T., Breakefield, X.O., Chiocca, E.A.: Virus vector mediated transfer of drug-sensitivity genes for experimental brain tumor therapy. In: Viral vectors: gene therapy and neuroscience applications. (M.G. Kaplitt and A.D. Loewy, eds.) Academic Press, San Diego, CA, 1995, pp. 239-259.

7. Breakefield, X.O., Esteves M., Pechan P., Kramm C., Yoshimoto Y., Lin Q., Davar G., Livermore J., Isacson O., Chiocca E.A., Bohn M., Kaye E.: Gene Therapy for the Nervous System- Status 1994. In: Genetic Therapy Fundacion BBV, in press, 1995.

8. Breakefield, X.O., Kramm, C.M., Chiocca E.A., Pechan, P.: Herpes simplex virus vectors for tumor therapy. In: The Internet book of Gene Therapy: Cancer Gene Therapeutics. (R. Sobol and K. Scanlon, eds.), 1995, pp 41-56.

9. Kramm, C., Breakefield, X.O., Chiocca E.A.: Genetic strategies against brain tumors. In: The Internet book of Gene Therapy: Cancer Gene Therapeutics. (R. Sobol and K. Scanlon, eds.), 1995, pp 235-246.

10. Chiocca, E.A. and Harsh, G.R. IV: Gene transfer technology and its application to brain
tumor therapy. In: The molecular basis of neurolosurgical disease. (C. Raffel and G.R. Harsh, eds.), 1996, pp . 238-247.

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