MACKLIS LAB

Bradley Molyneaux
Paola Arlotta
Noriyuki Kishi
Jason Emsley
Pembe Hande Ozdinler
Joao Meneze
Shivraj Sohur

Denis Jabaudon
Tina Lai
Arthur Czupryn

Liyun Li
Bartley Mitchell
Sanjay Magavi

Justine M. Nagurney

Kyle MacQuarrie
Alexander Eswar

MGH-HMS Center for Nervous System Repair
Macklis Lab

Dr Macklis | Recent Publications | Links

Jason Emsley

My background is in the development and gene expression of simple nervous systems, as well as in the use of trophic factors and neural precursors for central nervous system (CNS) repair. I am particularly interested in central nervous system development and disease, and how our understanding of neural development can inform our ability to manipulate the adult central nervous system for effective reconstruction of adult cortical circuitry. I am interested in adult cortical neurogenesis in general, and am focusing my efforts to understand/manipulate this process along three specific themes. My first project is aimed toward the use of mitogenic/trophic factors for the enhanced recruitment of subventricular zone derived cells during induced adult cortical neurogenesis. The second project aims to characterize temporal patterns of gene expression during "normal" developmental cortical neurogenesis, and to test whether or not this intricate pattern of expression is recapitulated in adult cortex undergoing targeted apoptosis. Finally, I am interested in the varied role of glial cells in the adult CNS, and have begun studies to assess and characterize their role during adult cortical neurogenesis.

Publications

Papers (Published and In Press)

Emsley, J.G., Arlotta, P., and Macklis, J.D. (2004) Star-cross'd neurons: Astroglial effects on neural repair in the adult mammalian CNS. Trends in Neurosciences 27: 238-240.

Mitchell, B.D., Emsley, J.G., Magavi, S.S.P., Arlotta, P., and Macklis, J.D. (forthcoming 2004) Constitutive and induced neurogenesis in the adult mammalian brain: manipulation of endogenous precursors toward CNS repair. Developmental Neuroscience, In Press.

Emsley, J.G. and Hagg, T. (2003) 6 1 integrin directs migration of neuronal precursors in adult mouse forebrain. Experimental Neurology 183: 273-285 (with cover).

Emsley, J.G. and Hagg, T. (2003) Endogenous and exogenous ciliary neurotrophic factor enhances forebrain neurogenesis in adult mice. Experimental Neurology 183: 298-310.

Lee, A., Emsley, J.G., Brown, R.E., and Hagg, T. (2003) Marked differences in olfactory sensitivity and speed of forebrain neuroblast migration in three inbred strains of mice. Neuroscience 118: 263-270.

Krueger-Naug, A.M.R., Emsley, J.G., Myers, T.L., Currie, R.W., and Clarke, D.B. (2003) Administration of BDNF alters the expression of Hsp27 in rat retinal ganglion cells following axotomy. Neuroscience 116: 49-58.

Krueger-Naug, A.M.R., Emsley, J.G., Myers, T.L., Currie, R.W., and Clarke, D.B. (2002) Injury to retinal ganglion cells induces expression of the small heat shock protein Hsp27 in the rat visual system. Neuroscience 110: 653-665.

Emsley, J.G., Lu, X., and Hagg, T. (2001) Retrograde tracing techniques influence reported death rates of adult rat nigrostriatal neurons. Experimental Neurology 168: 425-433.

Emsley, J.G. and Davis, M.D. (2001) Partial unilateral absence of the trapezius muscle in a human cadaver. Clinical Anatomy 14: 383-386.

Meinertzhagen, I.A., Emsley, J.G., and Sun, X-J. (1998) The developmental anatomy of the Drosophila brain: anatomy is gene expression. Journal of Comparative Neurology 402: 1-9.

Book Chapters

Emsley, J.G. and Macklis, J.D. (forthcoming 2004) Responses of the Adult SVZ to Neuronal Death and Injury. In Mammalian Subventricular Zones: Their roles in brain development, cell replacement and disease. S. Levison, editor. Kluwer.

Neurosurgery Clinical Units MGH Neurosurgical Service Spine Tumor Center at MGH Brain Tumor Center at MGH Research at MGH Neurosurgery Neuroscience Care Units at MGH Residents at Neurosurgery