MACKLIS LAB

Bradley Molyneaux
Paola Arlotta
Noriyuki Kishi
Jason Emsley
Pembe Hande Ozdinler
Joao Meneze
Shivraj Sohur

Denis Jabaudon
Tina Lai
Arthur Czupryn

Liyun Li
Bartley Mitchell
Sanjay Magavi

Justine M. Nagurney

Kyle MacQuarrie
Alexander Eswar

MGH-HMS Center for Nervous System Repair
Macklis Lab

Dr Macklis | Recent Publications | Links

Pembe Hande Ozdinler

My main goal is to find out the molecules and the molecular mechanisms behind cortico-spinal motor neuron survival and differentiation at different time points in their development. I am mainly focused on growth factors, neurotrophins and their related receptors for mediating survival and differentiation

Manuscripts:

" " Dual Role for Neurotrophin-3: Trophic factor for Proprioceptive neurons and tropic guidance cue for their axons" B. Genc, P.H.. Özdinler, A.E. Mendoza, R.S. Erzurumlu (Public Library of Science, accepted).

" " Dose and age-dependent axonal responses of embryonic Trigeminal neurons to localized NGF via p75NTR receptor" P.H.. Özdinler, E. Ulupinar, R.S. Erzurumlu (2004) Journal of Neurobiology (in press).

" " Local neurotrophin effects on central trigeminal axon growth patterns" P.H.. Özdinler, E. Ulupinar R.S. Erzurumlu, Developmental Brain Research (2004) 151(1-2):55-66.

" " Slit-2 as a branching/arborization factor for sensory axons in the mammalian central nervous system" P.H. Özdinler, R.S. Erzurumlu, Journal of Neuroscience (2002) 22: 4540-4549.

" " Neurotrophin induced axonal outgrowth is mediated via Rac and Rho." P.H.. Özdinler, R..S. Erzurumlu, Journal of Comparative Neurology (2001), 438, 377-387.

" " High level secretion of TaqI restriction endonuclease by recombinant Escherichia coli." Toksoy E., Özdinler, P.H, Onsan, Z. I.; Kirdar, B, Biotechnology Techniques (1999), 13(11), 803-808.

Selected Abstracts:

* " Characterization of cellular and molecular controls over cortico-spinal motor neuron survival and differentiation" P.H. Özdinler, B. Molyneaux, J. Nagurney, J.D. Macklis. Society for Neuroscience 2003, New Orleans-LA poster

* "Slit-2 as branch-inducing factor for embryonic trigeminal axons" R.S. Erzurumlu, P.H. Özdinler, Society for Neuroscience 2001, San Diego-CA. poster 592.14

* "Chemotropic and Chemorepellent effects of neurotrophins on embryonic sensory axons" P.H. Özdinler, R.S. Erzurumlu, American Society for Neurochemistry 2001, August 2001, Buenos Aires, Argentina

* "Effects of localized neurotrophin application in the embryonic whisler pad on trigeminal axon differentiation in vitro" E. Ulupinar; E. Sendemir; P.H. Özdinler; M.F. Jacquin; R.S. Erzurumlu, Neuroscience 2000, New Orleans-LA, poster 120.1

* "Chemotropic effects of NGF, NT-3 and BDNF on embryonic central trigeminal tract axons" R.S. Erzurumlu, P.H. Özdinler, M.F. Jacquin, European Neuroscience 2000, June 2000, London-England, poster 124.15.

* "NGF family of neurotrophins regulate axonal differentiation via Rac and Rho." P.H. Özdinler, R.S. Erzurumlu, NGF2000 Meeting, May 2000, Montreal-Canada, poster presentation.

* "Extracellular Production of TaqI Endonuclease by a Recombinant Escherichia coli Strain" E.Toksoy, P. H. Özdinler, Z. I. Onsan, B. Kirdar, 48th Canadian Chemical Engineering Conference, October 1998, Ontorio-Canada, poster presentation.

Fellowships and Awards:

Aug 2003-July 2006: Harvard Center for Neurodegeneration and Repair Training Program for Translational Research Postdoctoral Fellowship
Jan 2002: FASEB Graduate Student Travel Award

Nov 2001: Society For Neuroscience Eli Lilly Graduate Student Travel Award

Neurosurgery Clinical Units MGH Neurosurgical Service Spine Tumor Center at MGH Brain Tumor Center at MGH Research at MGH Neurosurgery Neuroscience Care Units at MGH Residents at Neurosurgery