MACKLIS LAB

Bradley Molyneaux
Paola Arlotta
Noriyuki Kishi
Jason Emsley
Pembe Hande Ozdinler
Joao Meneze
Shivraj Sohur

Denis Jabaudon
Tina Lai
Arthur Czupryn

Liyun Li
Bartley Mitchell
Sanjay Magavi

Justine M. Nagurney

Kyle MacQuarrie
Alexander Eswar

MGH-HMS Center for Nervous System Repair
Macklis Lab

Dr Macklis | Recent Publications | Links

U. Shivraj Sohur

Post-doctoral fellow, Macklis laboratory

I started in the laboratory in July 2004 after a 6-year hiatus from bench science; during this time I finished medical school and residency training. My graduate work was in transcriptional regulation of apoptosis in early B cell lineages by NF-kappaB transcription factor family and its modulation of bcl-2.

I am interested in corticostriatal projection neurons (CStrPN) because its dysfunction has been noted in multiple neurological conditions including Huntington's, Parkinson's diseases and cerebral palsy. I am currently learning micro-surgical techniques as well as studying the literature. I have experiments underway to study the perinatal development of CStrPN. I am also interested in following induced CStrPN development in the adult using a biophysical method of neurogenesis developed in our laboratory [Nature (2000) 405: 951-5].

Bios:

• 1992 -- B.S. in Biology & Chemistry - Angelo State University, San Angelo, Texas
• 2000 -- M.D., Ph.D. - Vanderbilt University School of Medicine, Nashville, Tennessee
• 2004 -- Neurology residency - Beth Israel Deaconess Medical Center & Harvard Medical School, Boston, Massachusetts

Publications:

Sohur US. Ferri's Clinical Diagnosis 2005. Chapters on Giant Cell Arteritis and Trigeminal Neuralgia.

Sohur US, Dixit MN, Chen CL, Byrom MW, Kerr LA. 1999. Rel/NF-kappaB represses bcl-2 transcription in pro-B lymphocytes. Gene Expr 8(4):219-29

Sohur US, Chen CL, Hicks DJ, Yull FE, Kerr LD. 2000. Nuclear factor-kappaB/Rel is apoptogenic in cytokine withdrawal-induced programmed cell death. Cancer Res 60(5):1202-5

Kemp WE Jr, Jones W, Sohur S and Tisdale J 1995. Late generalized
tuberculosis: unusual features of an often-overlooked disease. Southern Med Journal 88, 1221-1225

Neurosurgery Clinical Units MGH Neurosurgical Service Spine Tumor Center at MGH Brain Tumor Center at MGH Research at MGH Neurosurgery Neuroscience Care Units at MGH Residents at Neurosurgery