Nicholas T. Zervas, M.D. ~ Research Activities in the Neurosurgical Service at MGH

Neurosurgery Surgical Research Laboratory
Nicholas T. Zervas, M.D.

Treatment of Post-Surgical Vasoconstriction
CV | Recent Publications | Links

Background & Clinical Information
Neurosurgery Surgical Research Laboratory
White 539
Telephone: 617-726-8581
Fax: 617-726-6789
Email: zervas@helix.mgh.harvard.edu
PPD Ofice Info

Neurosurgery Surgical Research Laboratory

In the Neurosurgery Surgical Research Laboratory there are multiple ongoing basic and preclinical research projects involving studies of cerebral vasospasm and stroke. These studies range from basic bench-top assays of components involved in vasospasm pathways, to surgical models of disease pathways, to innovative use of new technologies to treat VSP, to imaging studies (PET, fCT, fMRI) of physiological changes involved in these disease processes.

Current studies in progress in the Neurosurgical Research Laboratory include:

Treatment of Post-Surgical Vasoconstriction - Dr Zervas's Studies.
Laboratory for Cerebrovascular Biophysics - Dr Peterson's Studies.
Neurophysiology Research Laboratory - Dr Ogilvy's & Dr Maynard's Studies
Photoelectron Research Project - Dr Cosgrove's Studies

The Neurosurgery Surgical Research Laboratory also provides surgical support facilities for Investigators conducting studies of interest to the Neurosurgical Service. Recent examples of studies conducted in the Neurosurgery Surgical Research Laboratory are:

Center for Innovative Minimally Invasive Therapy (CIMIT)

Albert Lee, M.D. - Brain cooling. Hypothermia is the most consistent, robust and broadly applicable experimental neuroprotective strategy for ischemic brain injury. A decrease in stroke injury in animal models occurs with only a 2-3 degree reduction in brain temperature. Initial clinical reports from Germany indicate that cerebral hypothermia can be attained by total body cooling, and is feasible and safe in stroke patients. We wish to test the ability of hypothermia to block the progression of ischemic injury as measured by diffusion-weighted MRI (DWI).
Gilberto Gonzalez, M.D., Ph.D. - Selective laser thrombolysis. The use of thrombolytic drugs such as urokinase, tissue plasminogen activator introduces an inherent risk of brain hemorrhage. There is a known (0.5%) risk in cardiac thrombolysis, it reached 6% in the American t-PA trial. In addition, bleeding risk excludes a number of devastated stroke patients from thrombolytic therapy, especially post-surgical cases. Laser assisted thrombolysis offers to improve the access of thrombolytic drug to the clot by causing microcavitation in the clot. This should allow recanalization of blocked vessels with lower doses of thrombolytic drug and lower risk of hemorrhage. Selective laser assisted thrombolysis has been developed for the treatment of acute myocardial infarction by applying pulses of low enough energy and pulse rate to selectively deposit energy in the clot. Laser energy pulses of short duration, nanoseconds-microseconds, deposit energy into the thrombus and begin the ablation process before sufficient heat diffuses to adjacent tissues, thereby limiting thermal damage.

Massachusetts Eye and Ear Infirmary (MEEI), the MGH Laser Center and the Neurology Acute Stroke Service

Steven Zeitels, MD., Rox Anderson and Walter Koroshetz, MD - Endoscopic Reversible Laryngeal Closure to Prevent Chronic Aspiration . The use of lasers to "weld" or create a laryngeal closure that would prevent possible aspiration of gastric contents that commonly leads to pneumonia in patients following cerebral strokes.

Day Neuromuscular Research Laboratory

Robert H. Brown, M.D., Ph.D. and Merit E. Cudkowicz, M.D. - Preclinical Studies of Intrathecal Recombination Human Superoxide Dismutase in Sheep. Surgical model for placement of intraventricular and spinal catheters for chronic infusion of superoxide dismutase (SOD). Studies in preparation for human clinical trials involving ALS patients.

Links

Selected Publications

Zervas NT. Management of Cushing's disease. In: Operative Neurosurgical Techniques, 3rd edition. Schmidek and Sweet (eds). W.B. Saunders Co. 1995.

Miller GM, Alexander JM, Bikkal HA, Katznelson L, Zervas NT, Klibanski A. Somatostatin receptor subtype gene expression in pituitary adenomas. J Clin Endocrinol Metab. 1995.

Kaoutzanis MC, Peterson JW, Anderson RR, McAuliffe DJ, Sibilia RF, Zervas NT. Basic mechanism of in vitro pulsed-dye laser-induced vasodilation. J Neurosurgery 1995 82(2):256-261.

Zervas NT and Biller BMK. Endocrine diagnosis in neurosurgery. In: Wilkins RH, Rengachary SS (eds). Neurosurgery (2nd edition). New York: McGraw Hill. 1994.

Cai WY, Alexander JM, Hedley-Whyte ET, Scheithauer BW, Jameson JL, Zervas NT, Klibanski A. Ras mutations in human prolactinomas and pituitary carcinomas. J Clin Endocrinology Metab. 1994 78(1):89-93.

Chiocca EA, Boviatsis EJ, Westmark RM, Short MP, Richardson EP, Zervas NT. Deep sylvian fissure meningioma without dural attachment in an adult: Case report. Neurosurgery 1994 35(5):944-946.

Sakas DE, Crowell RM, Kim K, Korosue K, Zervas NT. The perfluorocarbon fluoromethyloadamantane offers cerebral protection in a model of isovolemic hemodilution in rabbits. Stroke. 1994 25(1):197-201.

Hsu DW, Hakim F, Biller BMK, de la Monte S, Zervas NT, Klibanski A, Hedley-Whyte ET. Significance of proliferating cell nuclear antigen index in predicting pituitary adenoma recurrence. J Neurosurgery. 1993 78(5):753-761.

Yamakawa K, Peterson JW, Sibilia R, Kaoutzanis M, Zervas NT. Inactivity of PDGF-receptors in canine basilar artery. In: J M Findlay (ed). Cerebral Vasospasm, Elsevier Science Publishers BV, Amsterdam. 1993 145-147.

Kaoutzanis M, Peterson JW, Anderson R, McAuliffe DJ, Sibilia R, Yoota M, Zervas NT. Vasodilation mechanism after the in vitro application of pulsed-dye laser. In: JM Findlay (ed). Cerebral Vasospasm, Elsevier Science Publishers BV, Amsterdam. 1993 405-408.

Peterson JW, Sibilia R, Yamakawa K, Kaoutzanis M, Zervas NT. Complement-induced hemolysis of subarachnoid erythrocytes. In: JM Findlay (ed). Cerebral Vasospasm, Elsevier Science Publishers BV, Amsterdam. 1993 443-447.

Zervas NT, Pile-Spellman J. A 64-year-old woman with the abrupt onset of paraparesis after l0 months of increasing episodic leg weakness. Case Records of the Massachusetts General Hospital, Case #12-1992. New Engl J Med. 1992 326(12):816-824.

Biller BMK, Alexander JM, Zervas NT, Hedley-Whyte ET, Arnold A, Klibanski A. Clonal origins of adrenocorticotropin-secreting pituitary tissue in Cushing's disease. J Clin Endocrinol Metab. 1992 75(5):1303-1309.

Klibanski A, Zervas NT. Diagnosis and management of hormone- secreting pituitary adenomas. Seminars in Medicine of the Beth Israel Hospital, Boston. New Engl J Med. l99l 324(12):822-831.

Macfarlane R, Teramura A, Owen CJ, Chase S, de la Torre R, Gregory KW, Peterson JW, Birngruber R, Parrish JA, Zervas NT. Treatment of vasospasm with a 480-nm pulsed-dye laser. J Neurosurgery l99l 75:613-622.

Zervas NT. Cushing's disease. Neurosurgical Consultations. . l99l 23:1-6

Zervas NT. Pituitary surgery. In: Oxford Textbook of Surgery, Morris PJ,Malt RA (eds). Oxford University Press, l994.

Klibanski A, Zervas NT. Diagnosis and management of hormone- secreting pituitary adenomas. In: Barrow and Selman, eds. Neuroendocrinology, Williams and Wilkins, l992.

Klibanski A, Alexander JM, Bikkal HA, Hsu D, Swearingen B, Zervas NT. Somatostatin regulation of glycoprotein hormone and free subunit secretion in clinically nonfunctioning and somatotroph adenomas in vitro. J Endocrinol Clin Metab. l992 73:1248-1255.

Hornig GW, Zervas NT. Slit defect of the diaphragma sellae with valve effect: Observation of a "slit valve." Neurosurgery. l992 265-267.

Butler WE, Ogilvy CS, Chapman P, Verhey L, Zervas NT. Stereotactic alignment for Bragg peak radiosurgery. Radiosurgery: baseline and trends. Steiner L, et al (eds), Raven Press, New York, l992 85-91.

Teramura A, Macfarlane R, Owen CJ, de la Torre R, Gregory KW, Birngruber R, Parrish JA, Peterson JW, Zervas NT. Application of the 1 usec pulsed-dye laser to the treatment of experimental cerebral vasospasm. J Neurosurgery l991 75(2):271-276.

Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A. Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest. l990 86:336-340.

Maxwell M, Karacostas D, Ellenbogen RG, Brzezinski A, Zervas NT, Black PMcL. Precocious puberty following head injury: Case report. J Neurosurgery l990 73:l23-l29.

Sakas DE, Charnvises K, Borges LF, Zervas NT. Biologically inert synthetic dural substitutes: Appraisal of a medical-grade aliphatic polyurethane and a polysiloxane-carbonate block copolymer. J Neurosurgery l990 73:936-941.

Peterson JW, Roussos L, Kwun B-D, Hackett JD, Owen CJ, Zervas NT. Evidence for the role of hemolysis in experimental cerebral vasospasm J Neurosurgery l990 72:775-781.

Peterson JW, Kwun B-D, Hackett JD, Zervas NT. The role of inflammation in experimental cerebral vasospasm. J Neurosurgery l990 72:767-774.

El-Azouzi M, Hsu DW, Black PMcL, Jolesz F, Hedley-Whyte ET, Klibanski A, Zervas NT. The importance of dopamine in the pathogenesis of experimental prolactinomas. J Neurosurgery l990 72(2):273-281.

Yannas IV, Chang AS, Perutz S, Krarup C, Norregaard TV, Zervas NT. Requirement for a 1-um pore channel opening during peripheral nerve regeneration through a biodegradable chemical analog of ECM. Proc Am Chem Soc Div Polym Mat. l990 62:583-586.

Peterson JW, Nishizawa S, Hackett JD, Bun T, Teramura A, Zervas NT. Cyclosporine A reduces cerebral vasospasm after subarachnoid hemorrhage in dogs. Stroke, l990 21:133-137.

Teramura A, Macfarlane R, Owen C, de la Torre R, Gregory K, Peterson J, Parrish J, Uemura K, Zervas NT. Pulsed dye laser treatment of experimental cerebral vasospasm. In: Sano K, Takakura K, Kassell NF, Sasaki T, (eds.) Cerebral vasospasm. Tokyo: Tokyo University Press. l990 405-406.

Peterson JW, Nishizawa S, Teramura A, Candia G, Spanos A, Zervas NT. Calmodulin-antagonism and immunosuppression in cerebral vasospasm. In: Sano K, Takakura K, Kassell NF, Sasaki T, (eds.) Cerebral vasospasm. Tokyo: Tokyo University Press. l990 375-378.

Peterson J, Kwun B-D, Nishizawa S, Teramura A, Endoh M, Roussos L, Spanos A, Bun T, Zervas NT. Separate roles for inflammation and hemolysis in cerebral vasospasm. In: Sano K, Takakura K, Kassell NF, Sasaki T, (eds.) Cerebral vasospasm. Tokyo: Tokyo University Press. l990 171-174.

McGrail KM, Zervas NT. The empty sella syndrome. In: Youmans JR, ed. Neurological surgery, Third edition. Saunders Company, l990 3505-3513.

Chang AS, Yannas IV, Krarup C, Sethi R, Perutz S, Loree H, Norregaard TV, Zervas NT. Conduction properties in peripheral nerve fibers regenerated by biodegradable polymer matrix. Mat Res Soc Symp Proc. l989 ll0:3-8.

Klibanski A, Jameson LJ, Biller BMK, Crowley WF, Jr, Zervas NT, Rivier J, Vale WW, Bikkal H. Gonadotropin and a-subunit responses to chronic gonadotropin-releasing hormone analog administration in patients with glycoprotein hormone-secreting pituitary tumors. J Clin Endocrinol Metab. l989 68(l):8l-86.

El-Azouzi M, Chung RY, Farmer GE, Martuza RL, Black PMcL, Rouleau GA, Hettlich C, Hedley-Whyte ET, Zervas NT, Panagopoulos K, Nakamura Y, Gusella JF, Seizinger BR. Loss of distinct regions on the short arm of chromosome l7 associated with tumorigenesis of human astrocytomas. Proc Nat Acad Sci USA. l989 (86):7l86-7l90.

Oppenheim DS, Greenspan SL, Zervas NT, Schoenfeld DA, Klibanski A. Elevated serum lipids in hypogonadal men with and without hyperprolactinemia. Ann Intern Med. l989 lll(4)-288-292.

Peterson JW, Kwun B-D, Teramura A, Hackett JD, Morgan JA, Nishizawa S, Bun T, Zervas NT. Immunological reaction against the aging human subarachnoid erythrocyte: A model for the onset of cerebral vasospasm after subarachnoid hemorrhage. J Neurosurgery l989 7l:7l8-726.

Peterson JW, Candia G, Spanos AJ, Zervas NT. The calmodulin antagonist trifluoperazine provides mild prophylactic protection against cerebral vasospasm after subarachnoid hemorrhage, but no therapeutic value. Neurosurgery. l989 25:9l7-922.

Chang AS, Yannas IV, Krarup C, Sethi R, Norregaard TV, Zervas NT. Polymeric templates for peripheral nerve regeneration. Electro- physiological study of functional recovery. Proceedings of the ACS Division of Polymeric Materials: Science and Engineering. l988 59:906-9l0.

Tu Y-K, Heros RC, Candia G, Hydod A, Lagree K, Callahan R, Zervas NT, Karacostas D. Isovolemic hemodilution in experimental focal cerebral ischemia. Part l: Effects on hemodynamics, hemorheology, and intracranial pressure. J Neurosurgery l988 69:72-81

Black PMcL, Zervas NT, Candia G. Management of large pituitary adenomas by transsphenoidal surgery. Surg Neurology l988 29:443-447.

Zervas NT. Stereotactic thermal hypophysectomy. In: Operative neurosurgical techniques. Schmidek HH Sweet WH (eds). Grune & Stratton. l988 pp 345-348.

Jameson JL, Klibanski A, Black PMcL, Hsu D, Lindell CM, Zervas NT, Ridgway EC. Glycoprotein hormone gene expression and hormone production in pituitary adenomas. In: Advances in the Biosciences, Vol. 69. Landolt AM, Heitz PU, Zapf J, Girard J, Del Pozo E. (eds). Pergamon Press, l988 387-393.

Karacostas D, Baker K, Lagree K, Milonas J, Zervas NT. The cortical activity in experimental subarachnoid hemorrhage. Functional Neurology l988 3(3):275-283.

Black PMcL, Zervas NT. Surgical management of sellar and parasellar lesions. In: Operative neurosurgical techniques. (2nd ed.). Schmidek HH and Sweet WH, (Eds). Grune & Stratton. l988 299-307.

Mayberg MR, Liszczack TM, Black PMcL, Zervas NT. Acute structural changes in feline cerebral arteries after subarachnoid hemorrhage. In: Cerebral Vasospasm. Wilkins RH (ed.). Raven Press. l988 23l-246.

Kolluri S, De Girolami U, Heros R, Vacanti F, Zervas N. Fluosol and experimental spinal cord ischemia. In: Acta Neuropathologica, Berlin. l988 75:49l-494.

Klibanski A, Shupnik MA, Bikkal HA, Black PMcL, Kliman B, Zervas NT. Dopaminergic regulation of alpha-subunit secretion and mRNA levels in alpha-secreting pituitary tumors. J Clin Endocrinol Metab. l988 66(l):96-l02.

Yannas IV, Orgill DP, Silver J, Norregaard TV, Zervas NT, Schoene WC. Regeneration of sciatic nerve across 15mm gap by use of a polymeric template. In: Advances in Biomedical Polymers. Gebelein CG (ed). Plenum Publishing Corp. l987.

Jameson JL, Klibanski A, Black PMcL, Zervas NT, Lindell CM, Hsu DW, Ridgway EC, Habener JF. Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest. l987 80:l472-l478.

Black PMcL, Hsu DW, Klibanski A, Kliman B, Jameson L, Ridgway EC, Hedley-Whyte ET, Zervas NT. Hormone production in clinically nonfunctioning pituitary adenomas. J Neurosurgery l987 66:244-250.

Baker KF, Zervas NT, Pile-Spellman J, Vacanti FX, Miller D. Angiographic evidence of basilar artery constriction in the rabbit: A new model of vasospasm. Surg Neurology l987 27:l07-ll2.

Zervas NT. Multicenter surgical results in acromegaly. In: Ludecke DK, Tolis G, eds. Growth hormone, growth factors, and acromegaly. New York, Raven Press. l987 253-256.

Tu Y-K, Heros RC, Candia G, Karacostas D, Hyodo A, LaGree K, Zervas NT. Viscosity effects on blood flow dynamics: Influence of isovolemic hemodilution on focal cerebral ischemia. In: Hartmann A, Kuschinsky W.(eds). Cerebral ischemia and hemorheology, Berlin, Heidelberg, Springer-Verlag. l987 3l5-325.

Goldring S, Zervas N, Langfitt T. The extracranial-intracranial bypass study. A report of the committee appointed by the American Association of Neurological Surgeons to examine the study.N Engl J Med. l987 3l6(l3):8l7-820.

Zervas NT. Failure of fluosol to influence the incidence of cerebral infarction on mortality in gerbils subjected to temporary carotid occlusion. Surg Neurology l986 25:553-556.

Kolluri S, Heros RC, Hedley-Whyte ET, Vonsattel JP, Miller D, Zervas NT. Comparison of the effect of fluosol DA and dextran 40 on regional cerebral blood flow, infarction size, and mortality in cats with temporary occlusion of the middle cerebral artery. Surg Neurology l986 26:3-8.

Debron G, Zervas NT, Taveras JM. High-flow angiopathy: Cerebral blood vessel changes in experimental chronic arteriovenous fistula. Am J Neuroradiol. l986 7:8ll-8l5.

Kolluri S, Heros RC, Hedley-Whyte ET, Vonsattel JP, Zervas NT. Effect of fluosol on oxygen availability, regional cerebral blood flow and infarct size in a model of temporary focal cerebral ischemia. Stroke. l986 l7(5):976-980.

Schonene WC. Polymeric template facilitates regeneration of sciatic nerve across 15-mm gap. In: Polymeric materials, science and engineering. American Chemical Society. Vol. 53, l985.

Alexander E, III, Black PMcL, Liszczak TM, Zervas NT. Delayed CSF lavage for arteriographic and morphological vasospasm after experimental SAH. J Neurosurgery l985 63:949-958.

Zervas NT. Intracerebral hemorrhage. In: Long D, ed. Current Therapy in Neurological Surgery, l984-l986. Philadelphia: BC Decker. l985 69-71.

Black PMcL, Zervas NT, Ridgway EC, Martin JB. (Editors) Secretory Tumors of the Pituitary Gland. New York, Raven Press, l984.

Mayberg MR, Zervas NT, Moskowitz MA. Trigeminal projections to supra-tentorial pial and dural blood vessels in cats demonstrated by horseradish peroxidase histochemistry. J Comp Neurology l984 223:45-56.

Klibanski A, Beitins IZ, Meriam GR, McArthur JW, Zervas NT, Ridgway EC. Gonadotropin and prolactin pulsations in hyperprolactinemic women before and during bromocriptine therapy. J Clin Endocrinol Metab. l984 58:ll4l-ll47.

Varsos V, Heros RC, DeBrun G, Zervas NT. Construction of experimental "giant" aneurysms. Surg Neurology l984 22:l7-20.

Liszczak TM, Black PMcL, Varsos VG, Zervas NT. The microcirculation of cerebral arteries: A morphologic and morphometric examination of the major canine cerebral arteries. Am J Anat. l984 l70:223-232.

Ropper AH, Kennedy SK, Zervas NT. (Editors), Neurological and Neurosurgical Intensive Care. Baltimore, University Park Press. l983.

Heros RC, Varsos VG, Borges L, Hedley-Whyte ET. Can perfluoro- chemicals reduce cerebral ischemia? In: Reivich M, Hurtiz HI, eds. Cerebrovascular Diseases. Thirteenth Research (Princeton) Conference. New York, Raven Press, l983 409-4l9.

Moskowitz MA, Liu-Chen LY, Mayberg MR, Zervas NT, Han DH, Brody MR. Cat pia-arachnoid contains immunoreactive substance P with neurons projecting from the fifth cranial nerve. In: Reivich M, Hurtiz HI, eds. Cerebrovascular Diseases. Thirteenth Research (Princeton) Conference. New York, Raven Press. l983 363-37l.

Klibanski A, Ridgway EC, Zervas NT. Pure alpha subunit secreting pituitary tumors. J Neurosurgery l983 59:585-589.

Varsos VG, Liszczak TM, Han DH, Kistler JP, Vielma J, Black PM, Heros RC, Zervas NT. Delayed cerebral vasospasm is not reversible by aminophylline, nifedipine, or papaverine in a "two-hemorrhage" canine model. J Neurosurgery l983 58:11-17.

Klibanski A, Beitins IZ, Zervas NT, McArthur JW, Ridgway EC. Alpha subunit and gonadtropin responses to luteinizing hormone-releasing hormone in hyperprolactinemic women before and after bromocriptine. J Clin Endocrinol Metab. l983 56:774-780.

Grillo HC, Ojemann RG, Scannell JG, Zervas NT. Combined approach to "dumbbell" intrathoracic and intraspinal neurogenic tumors. Ann Thorac Surg. l983 36:402-407.

Heros RC, Zervas NT. Subarachnoid hemorrhage. Ann Rev Med. l983 34:367-375.

Kistler JP, Crowell RM, Davis KR, Heros R, Ojemann, RG, Zervas NT, Fischer CM. The relation of cerebral vasospasm to the extent and location of subarachnoid blood visualized by CT scan. A prospective study. Neurology, l983 33:424-436.

Beatty RM, Zervas NT. Stereotactic aspiration of a brain stem hematoma. Neurosurgery. l983 l3:204-207.

Swann KW, Ropper AH, Zervas NT. Initial results of a clinical trial of Fluosol-DA 20 percent in acute cerebral ischemia. In: Bolin RB, Geyer RP, Nemo GJ, eds. Advances in Blood Substitute Research. New York, Alan R. Liss, l983 399-404.

Heros RC, Zervas NT, Varsos V. Cerebral vasospasm after subarachnoid hemorrhage: An update. Ann Neurology l983 l4:599-608.

Heros RC, Zervas NT. Cerebral vasospasm. Neurol and Neurosurgery Update Series. l983 4(33):l-7.

Black PMcL, Zervas NT. The neurosurgical management of large pituitary adenomas. Surg Rounds, Nov. l983 l03-l20.

Ropper AH, Zervas NT. Cerebral blood flow after experimental basal ganglia hemorrhage. Ann Neurology l982 ll:266-27l.

Liszczak TM, Varsos VG, Black PM, Heros RC, Zervas NT. Characteristics of irreversibly constricted cerebral blood vessels. In: Bailey GW, ed. 40th Ann Proc Electron Microscopy Soc Am. Washington, l982 200-20l.

Macon JB, Poletti CE, Sweet WH, Ojemann RG, Zervas NT. Conducted somatosensory evoked potentials during spinal surgery. Part 2. Clinical applications. J Neurosurgery l982 57:354-359.

Zervas NT. Stereotactic thermal hypophysectomy. In: Schmidek HH, Sweet WH, eds. Operative Neurosurgical Techniques. Indications, Methods, and Results, Vol. l. New York, Grune and Stratton, l982 35l-356.

Hori H, Zervas NT. Cerebral vasospasm: Mechanical versus humoral factors. In: Smith RR, Robertson JT, eds. Subarachnoid hemorrhage and cerebrovascular spasm. Springfield, IL: Charles C Thomas, l975 226-235.

Wurtman RJ, Lavyne MH, and Zervas NT. Brain catecholamines in relation to cerebral blood vessels. In: Whisnant JP, Sandok BA, eds. Cerebral Vascular Diseases. New York: Grune & Stratton, Inc., l975 13-26.

Gordon MJ, Skillman JJ, Zervas NT, Silen W. Divergent nature of gastric mucosal permeability and gastric acid secretion in sick patients with general surgical and neurosurgical disease. Ann Surg.

Zervas NT, Hamlin H. Technical factors in stereotaxic hypophysectomy. Acta Neurochir. (Wien) (Suppl. 24). 1977 137-138.

Caplan LR, Zervas NT. Survival with permanent midbrain dysfunction after surgical treatment of traumatic subdural hematoma: the clinical picture of a duret hemorrhage? Ann Neurology 1977 1:587-589.

Zervas NT. Long-term review of dentatectomy in dystonia musculorum deformans and cerebral palsy. Acta Neurochir. (Wien) (Suppl. 24). 1977 49-51.

Black PMcL, and Zervas NT. Diagnosis and surgical treatment of pituitary lesions. Comp. Ther. 1977 3:8-15.

Zervas NT. Stereotaxic thermal hypophysectomy. In: Schmidek HH, Sweet WH, eds. Current Techniques in Operative Neurosurgery. New York: Grune & Stratton. 1977 181-186.

Wurtman RJ, Lavyne MH, Moskowitz MA, and Zervas NT. Brain monoamine neurotransmitters and the pathophysiology of stroke. In: Owman C, Edvinsson L, eds. Neurogenic Control of the Brain Circulation, Vol.30. Proceedings of the International Symposium, Stockholm, June 1977. Oxford: Pergamon Press. 1977 483-495.

Zervas NT. Pituitary surgery. In: Practice of Surgery. Hagerstown, MD: Harper & Row. 1976.

Heros RC, Lavyne MH, and Zervas NT. Limitations of diazoxide reversal of vasospasm. Stroke. 1976 7:118-120.

Heros RC, Zervas NT, Lavyne MH, and Pickren KS. Reversal of experimental cerebral vasospasm by intravenous nitroprusside therapy. Surg. Neurology 1976 6:227-229.

Zervas NT, Hori H, Negoro M, and Wurtman RJ. Neurogenic regulation of cerebral blood flow following ischemia. Stroke. 1976 7:113-118.

Heros RC, Zervas NT, Negoro M. Cerebral vasospasm. Surg Neurology 1976 5:354-362.

Zervas NT, Mendelson G. Treatment of acute hemorrhage of pituitary tumors. Lancet March 15. 1975 1:604.

Zervas NT, Lavyne MH, Negoro M. Neurotransmitters and the normal and ischemic cerebral circulation. N Engl J Med. 1975 293:812-816.

Lavyne MH, Moskowitz MA, Zervas NT, and Wurtman RJ. Rotational behavior in gerbils following unilateral common carotid artery ligation. J Neural Trans. 1975 36:83-89.

Lavyne MH, Moskowitz MA, Larin F, Zervas NT, and Wurtman RJ. Brain H3-catecholamine metabolism in experimental cerebral ischemia. Neurology. 1975 25:483-485.

Moskowitz MA, Meyer E, Wurtman RJ, Lavyne MH, and Zervas NT. Attenuation by catecholamine antagonists of the hypothermia that follows cerebral infarction in gerbils. Life Sci. 1975 17:597-602.

Lavyne MH, Wurtman RJ, Moskowitz MA, and Zervas NT. Brain catecholamines and cerebral blood flow. Life Sci. 1975 16:475-486.

Hori H, Wurtman RJ, Zervas NT. Alpha methyl p tyrosine and experimental stroke. In: Langfitt TW, McHenry LC, Revich M, Wollman H, eds. Cerebral Circulation & Metabolism. Berlin: Springer-Verlag. 1975 77-78.

Zervas NT, Stereotaxic thermal hypophysectomy. In: Krayenbuehl H, Maspes PE, Sweet WH, eds. Basel: S Kager, Neurological Surgery. 1975 Vol.6, 217-251.

Caplan LR, Zervas NT. Neurological considerations for the intensive care patient. In: Skillman J, ed. Intensive Care. Boston: Little, Brown & Co.. 1975 451-491.

Zervas NT, Hori H, Negora M, Wurtman RJ, Larin F, and Lavyne MH. Reduction in brain dopamine following experimental cerebral ischaemia. Nature. 1974 247:283-284.

Zervas NT, Hori H, and Rosoff CB. Experimental inhibition of serotonin by antibiotic: prevention of cerebral vasospasm. J Neurosurgery 1974 41:59-62.

Wurtman RJ and Zervas NT. Monoamine neurotransmitters and the pathophysiology of stroke and central nervous system trauma. J Neurosurgery 1974 40:34-36.

Zervas NT, Hamlin H. Stereotaxic thermal pituitary ablation. Acta Neurochir. (suppl). 1974 21:165-168.

Belson R, Zervas NT. Demonstration of 5-hydroxytryptamine in blood platelets by a formaldehyde-induced fluorescence technique. Stain Tech. 1973 48:311-315.

Zervas NT, Shintani A, Kuwayama A, Hale R, Pickren KS, Merry A. Experimental induction heating hypophysectomy. Confin Neurology 1973 35:129-137.

Zervas NT, Kuwayama A, Rosoff CB, Salzman EW. Cerebral arterial spasm. Modification by inhibition of platelet function. Arch. Neurology 1973 28:400-404.

Merry GA, Hale R, Zervas NT. Induction thermocoagulation - a seed power study. IEEE Trans Biomed Eng. 1973 20:302-303.

Zervas NT. Pituitary neoplasm (Discussion). In: Diagnosis and treatment of pituitary tumors; proceedings of a conference in Bethesda, MD, January 15-17, 1973. International congress series number 303. Edited by Kohler PD, Ross GT. 1973 291-294.

Zervas NT, Hedley-Whyte J. Successful treatment of cerebral herniation in five patients. N Engl J Med. 1972 286:1075-1077.

Shintani A, Zervas NT, Kuwayama A, Pallotta J, Spark R. Transorbital pituitary stalk section in primates. J. Neurosurgery 1972 37:601-605.

Zervas NT, Kuwayama A. Pathological characteristics of experimental thermal lesions. J Neurosurgery 1972 37:418-422.

Shintani A, Zervas NT. Consequence of ligation of the vertebral artery. J Neurosurgery 1972 36:447-450.

Zervas NT, Hamlin H, Pallotta J, Gordy P, Spark R, Sherwood L. Radiofrequency thermal hypophysectomy for acromegaly. Confin Neurology 1972 34:412-417.

Shintani A, Zervas NT, Kuwayama A. Rapid microvascular repair using plastic adhesive. Stroke. 1972 3:34-40.

Kuwayama A, Zervas NT, Shintani A, Pickren KS. Papaverine hydrochloride and experimental hemorrhagic cerebral arterial spasm. Stroke. 1972 3:27-33.

Kuwayama A, Zervas NT, Belson R, Shintani A, Pickren KS. A model for experimental cerebral arterial spasm. Stroke. 1972 3:49-56.

Hamlin H, Zervas NT. Results of stereotactic treatment for sellar tumors. In Present Limits of Neurosurgery, Proceedings of the European Congress of Neurosurgery, June 28-July 2. Edited by I. Fusek and Z. Kunc. Avicenum, Czechoslovak Medical Press, Prague. 1971.

Zervas NT, Kuwayama A, Rosoff C, Salzman E. Cerebral vascular spasm and reduction of platelet serotonin. Surg Forum. 1971 22:426-427.

Shintani A, Kuwayama A, Zervas NT. Transsphenoidal stereotaxic approach to the normal pituitary, pituitary tumor, and parasellar disease. Brain and Nerve. 1971 23:881-887.

Zervas NT. Hypophysectomie et cancer. Medecine et Hygiene. 1970 916:745-746.

Zervas NT, Shintani A, Pickren KS. Electrical impedance of the pituitary gland. J Neurosurgery 1970 33:304-306.

Zervas NT, Shintani A, Kallar B, Berry RG. Multiple meningiomas occupying separate neuraxial compartments. J Neurosurgery 1970 33:216-220.

Lee KF, Zervas NT, Horner FA, Berry RG. Asymptomatic chromophobe adenoma in an eight-year-old child biopsied by stereotaxic technique and treated with cobalt-60. J Neurosurgery 1970 32:585-588.

Zervas NT. Paramedial cerebellar nuclear lesions. Confin Neurology 1970 32:114-117.

Zervas NT. Stereotaxic anatomy of sella turcica. Invest Radiol. 1969 4:414.

Skillman JJ, Zervas NT, Weintraub RM, Mayman CI. Paraplegia after resection of aneurysms of the abdominal aorta. N Engl J Med. 1969 281:422-425.

Zervas NT. Stereotaxic radiofrequency surgery of the normal and the abnormal pituitary gland. N Engl J Med. 1969 280:429-437.

Zervas NT, Pickren KS. Transorbital hypophysectomy in primates. Endocrinology. 1969 85:949-951.

Zervas NT, and Gordy PD. Radiofrequency thermal hypophysectomy. J Neurosurgery 1969 30:511-514.

Zervas NT, Gordy PD and Field RA. Radiofrequency pituitary ablation (its use in diabetic retinopathy). In Symposium on the Treatment of Diabetic Retinopathy. Warrenton, VA. September 29-October 1, 1968. Edited by M Goldberg and SL Fine. Washington, DC. US Government Printing Office (PHS Publ No 1890). 1969 365-373.

Field RA, Behrendt T, Zervas NT, Gordy PD and Duane TD. Radiofrequency pituitary coagulation for angiopathic diabetic retinopathy. In Symposium on the Treatment of Diabetic Retinopathy. Warrenton, VA. September 29-October 1. 1968. Edited by M Goldbert and SL Fine. Washington, DC, US Government Printing Office (PHS Publ No 1890). 1969 203-212.

Zervas NT, Horner FG, and Gordy PD. Stereotaxic dentatectomy in extrapyramidal disorders. Dev Med Child Neurol (England). 1968 10:248-249.

Zervas NT, Horner FG, and Gordy PD. Cerebellar dentatectomy in primates and humans. Trans Am Neurol Assoc. 1967 92:27-30.

Zervas NT, and Gordy PD. Radiofrequency hypophysectomy for metastatic breast and prostatic carcinoma. Surg Clin North Am. 1967 47:1279-1285.

Zervas NT, Horner FA, and Pickren KS. The treatment of dyskinesia by stereotaxic dentatectomy. Confin Neurology 1967 29:93-100.

Edeiken J, Zervas NT, and Clearfield R. Cervical perineural or extradural cysts mimicking bone erosion of neurofibromata. Clin. Orthop. 1966 44:187-190.

Zervas NT. Eccentric radio-frequency lesions. Confin Neurology 1965 26:143-145.

Zervas NT. Technique of radio-frequency hypophysectomy. Confin Neurology 1965 26:157-160.

Zervas NT and Berry RG. Ectopic cartilage involving the spinal cord. Arch. Neurology 1965 13:673-677.

Zervas NT and Soloway AH. The microscopic distribution of water- soluble compounds by autoradiography. J Neuropath Exp Neurology 1964 23:151-155.

Zervas NT and Soloway AH. Autoradiographic localization of tritiated boron compounds. J Neuropath Exp Neurology 1963 22:352.

Mark VH, White JC, Zervas NT, Ervin FR, Richardson EP. Intrathecal use of phenol for the relief of chronic severe pain. N Engl J Med. 1962 267:589-593.

Baltzan MA, Olszewski J and Zervas NT. Chronic porto-hepatic encephalopathy. J Neuropath Exp Neurology 1957 16:410-421.

Marshall FC, Zervas NT and Olszewski J. Renal hypertension with cerebral arteriolar necrosis. Can Med Assoc J. 1957 76:576-579.

	Any suggestions for additions to the Web server should be forwarded to: PageServant by e-mail to C. Owen In, Around & About MGH or Maps of MGH, and the Boston Area. Information on Referrals to MGH Neurosurgery or to other services at the MGH Physician Referral Service
	To the MGH Neurosurgery Attending Staff or the MGH Physician Referral Service homepages. Click on the Bulfinch building to return to the MGH Neurosurgical Service hompage.

Disclaimer: The information and reference materials contained herein is intended solely for the information of the reader. It should not be used for treatment purposes, but rather for discussion with the patient's own physician.� Copyright